Prosenjit Pal
I did my PhD in Neuroscience focused on the population genetics and molecular biology of Parkinson's disease from University of Calcutta, Kolkata, India. During the end of my PhD, I received the prestigious Newton-Bhabha Fellowship and came to MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Scotland, UK and worked with Prof. Miratul Muquit. After finishing my PhD, I joined Prof. Dario Alessi's lab as a Postdoctoral Fellow where I focused on understanding the downstream mechanism of LRRK2 mediated hyperphosphorylated Rab GTPases. My work revealed a connection between lysosomal dysfunction and Parkinson's disease. I further concentrate on understanding the function of this lysosomal membrane integral protein. My preliminary data suggests this protein has a direct or indirect link with the ubiquitylation system whereas it interacts with a group of proteins that contains a conserved motif which we called TBM. This TBM-containing proteins are linked with autophagy, lysosomal trafficking, and ciliogenesis. My future goal is to study this protein further to understand the function of this protein during stress or pathogenic infection which might explain the sporadic form of Parkinson's disease.
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