Saturday, 22nd November
Inaugural Australian Ubiquitin Summit 2025
Days
Thursday, 20th November
Friday, 21st November
Saturday, 22nd November
Sunday, 23rd November
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Speakers
Registration
8:15AM - 4:00PM
Saturday, 22nd November
Mantra Lorne Lobby
TPD Opening
8:45AM - 9:00AM
Saturday, 22nd November
Heritage Ballroom
Back to Basics: Core Pillars of TPD
9:00AM - 10:35AM
Saturday, 22nd November
Heritage Ballroom
Chairs: Anne Hempel & Charlene Magtoto
Expansion of molecular glue target space for addressing the undruggable genome
-
Philip Chamberlain
Cryptic Interactions Uncovered in Full CRL4
CRBN
Ubiquitylation Complexes Govern Molecular Glue Degrader Efficacy
-
Lei Liu
Targeting TEAD transcription factors: Development and functional profiling of IAP recruiting degraders
-
Nishma Gupta
Spatial and temporal characterization of targeted protein degradation via leveraging CUL3
KLHL20
as the effector E3 ligase system
-
Johannes Yeh
Targeting new E3 Ligases and validating them for PROTAC development
-
Stefan Knapp
Morning Tea Break
10:35AM - 10:55AM
Saturday, 22nd November
Convention Centre
Frontiers of Innovation in TPD
10:55AM - 12:40PM
Saturday, 22nd November
Heritage Ballroom
Chairs: Michael Roy & Jackson Henneveld
Advances in the systematic discovery of molecular glue degraders
-
Eric Fischer
Interrogating the Druggable Proteome with Proximity Pharmacology
-
Fleur Ferguson
Structure-guided development of chemically tailored peptide binders of RNF43/ZNRF3 to enable versatile design of membrane protein-targeting PROTACs
-
Man Pan
Protein degradation induced by IAP-based PROTACs, SNIPERs.
-
Mikihiko Naito
Lunch & EMCR Networking with Speakers
12:40PM - 1:50PM
Saturday, 22nd November
Convention Centre
TPD in Disease Management
1:50PM - 3:25PM
Saturday, 22nd November
Heritage Ballroom
Chairs: Luke Isbel & Sunita KC Basnet
Development of a Dual-Indicator Platform for Identifying Internal Degrons
-
Hsueh-Chi Sherry Yen
PROTACs for TDP-43 Degradation: A Viable Therapeutic Strategy for Amyotrophic Lateral Sclerosis
-
Selina Zhang
Discovery of Potent and Selective Deubiquitinase Inhibitors by Increased Throughput Activity Proteomics
-
Hannah B.L. Jones
HUWE1 Amplifies Ubiquitin Signals on Proteins and Aggregates to Promote Their Degradation
-
Mengying Zhou
Cellular Factors and Mechanisms that Counteract Targeted Protein Degradation
-
Fumiaki Ohtake
Afternoon Tea Break
3:25PM - 3:45PM
Saturday, 22nd November
Convention Centre
TPD's Translational Journey
3:45PM - 4:35PM
Saturday, 22nd November
Heritage Ballroom
Chairs: Bernhard Lechtenberg & Maithili Sashindranath
To be provided
-
Gwenn Hansen
Accelerating TPD Discovery through RaPPIDS
TM
Platform: Unlocking the E3 Ligase Space
-
Kanae Gamo
EMCR Discussion Panel + Drinks
4:45PM - 5:30PM
Saturday, 22nd November
Heritage Ballroom
Chairs: Sylvie Callegari & Ngee Kiat (Jake) Chua
Conference Dinner
6:00PM - 10:00PM
Saturday, 22nd November
Lorne Common (Footy Oval)
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